Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 7 | ||
| Ligand | BDBM50283472 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1725548 (CHEMBL4140826) | ||
| EC50 | 650±n/a nM | ||
| Citation |  Abe, M; Seto, M; Gogliotti, RG; Loch, MT; Bollinger, KA; Chang, S; Engelberg, EM; Luscombe, VB; Harp, JM; Bubser, M; Engers, DW; Jones, CK; Rodriguez, AL; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Discovery of VU6005649, a CNS Penetrant mGlu ACS Med Chem Lett8:1110-1115 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 7 | |||
| Name: | Metabotropic glutamate receptor 7 | ||
| Synonyms: | GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 102244.48 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | P35400 | ||
| Residue: | 915 | ||
| Sequence: |
| ||
| BDBM50283472 | |||
| n/a | |||
| Name | BDBM50283472 | ||
| Synonyms: | CHEMBL4160748 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H12F5N3O | ||
| Mol. Mass. | 357.278 | ||
| SMILES | COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F |(9.45,-43.77,;10.47,-42.62,;9.99,-41.15,;8.48,-40.84,;7.99,-39.38,;9.02,-38.23,;8.54,-36.77,;9.43,-35.53,;10.97,-35.52,;8.53,-34.29,;7.07,-34.77,;5.74,-34,;4.41,-34.77,;4.41,-36.31,;3.08,-37.09,;5.74,-37.08,;7.08,-36.3,;5.74,-32.46,;7.08,-31.68,;4.41,-31.68,;5.73,-30.92,;10.52,-38.54,;11.55,-37.39,;11.01,-40,;12.52,-40.31,)| | ||
| Structure | 
| ||