| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
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| Ligand | BDBM50195695 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1728729 (CHEMBL4144007) |
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| IC50 | 160±n/a nM |
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| Citation |  Terakado, M; Suzuki, H; Hashimura, K; Tanaka, M; Ueda, H; Hirai, K; Asada, M; Ikura, M; Matsunaga, N; Saga, H; Shinozaki, K; Karakawa, N; Takada, Y; Minami, M; Egashira, H; Sugiura, Y; Yamada, M; Nakade, S; Takaoka, Y Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett8:1281-1286 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 1 |
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| Name: | Lysophosphatidic acid receptor 1 |
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| Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41120.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92633 |
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| Residue: | 364 |
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| Sequence: | MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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| BDBM50195695 |
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| n/a |
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| Name | BDBM50195695 |
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| Synonyms: | CHEMBL3941037 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31NO5 |
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| Mol. Mass. | 461.5494 |
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| SMILES | COc1cc(cc(OC)c1C)C(=O)N(CCCc1ccccc1)Cc1ccc(CC(O)=O)cc1 |
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| Structure | 
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