Reaction Details |
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Target | Tryptophan 2,3-dioxygenase |
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Ligand | BDBM50321329 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1734173 (CHEMBL4149709) |
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EC50 | 340±n/a nM |
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Citation | Pei, Z; Mendonca, R; Gazzard, L; Pastor, R; Goon, L; Gustafson, A; VanderPorten, E; Hatzivassiliou, G; Dement, K; Cass, R; Yuen, PW; Zhang, Y; Wu, G; Lin, X; Liu, Y; Sellers, BD Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2). ACS Med Chem Lett9:417-421 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 2,3-dioxygenase |
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Name: | Tryptophan 2,3-dioxygenase |
Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
Type: | PROTEIN |
Mol. Mass.: | 47874.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_825691 |
Residue: | 406 |
Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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BDBM50321329 |
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n/a |
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Name | BDBM50321329 |
Synonyms: | CHEMBL4177244 |
Type | Small organic molecule |
Emp. Form. | C7H8N4O |
Mol. Mass. | 164.1646 |
SMILES | Cc1cnn(c1)-c1cnoc1N |
Structure |
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