| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6 |
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| Ligand | BDBM50449544 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1740132 (CHEMBL4155882) |
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| IC50 | 19±n/a nM |
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| Citation |  Zhi, Y; Li, B; Yao, C; Li, H; Chen, P; Bao, J; Qin, T; Wang, Y; Lu, T; Lu, S Discovery of the selective and efficacious inhibitors of FLT3 mutations. Eur J Med Chem155:303-315 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6 |
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| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| BDBM50449544 |
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| n/a |
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| Name | BDBM50449544 |
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| Synonyms: | CHEMBL4160544 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N8OS |
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| Mol. Mass. | 504.65 |
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| SMILES | CC(C)c1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)nc(C)nc2s1 |
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| Structure | 
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