| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50451681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1746080 (CHEMBL4180590) |
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| IC50 | 301±n/a nM |
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| Citation |  Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors. Bioorg Med Chem Lett27:5332-5336 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50451681 |
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| n/a |
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| Name | BDBM50451681 |
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| Synonyms: | CHEMBL4208198 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34FN7 |
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| Mol. Mass. | 487.6149 |
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| SMILES | CCN1CCN(Cc2ccc(Nc3cc(ccn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 |
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| Structure | 
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