| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251] |
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| Ligand | BDBM50452516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1747678 (CHEMBL4182188) |
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| Ki | 900±n/a nM |
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| Citation |  Kwon, J; Mistry, T; Ren, J; Johnson, ME; Mehboob, S A novel series of enoyl reductase inhibitors targeting the ESKAPE pathogens, Staphylococcus aureus and Acinetobacter baumannii. Bioorg Med Chem26:65-76 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251] |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251] |
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| Synonyms: | Enoyl-ACP reductase | FABI_STAAR | fabI |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26446.66 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_1455655 |
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| Residue: | 243 |
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| Sequence: | YVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQ
SDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIV
AHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAI
SAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHV
DSG
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| BDBM50452516 |
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| n/a |
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| Name | BDBM50452516 |
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| Synonyms: | CHEMBL4211939 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClNO3 |
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| Mol. Mass. | 343.804 |
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| SMILES | Clc1ccccc1CC(=O)N1CCC(C1)c1ccc2OCOc2c1 |
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| Structure | 
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