| Reaction Details |
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 | Report a problem with these data |
| Target | Lethal factor |
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| Ligand | BDBM50452692 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1748082 (CHEMBL4182592) |
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| EC50 | 32±n/a nM |
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| Citation |  Jiao, GS; Kim, S; Moayeri, M; Thai, A; Cregar-Hernandez, L; McKasson, L; O'Malley, S; Leppla, SH; Johnson, AT Small molecule inhibitors of anthrax edema factor. Bioorg Med Chem Lett28:134-139 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lethal factor |
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| Name: | Lethal factor |
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| Synonyms: | Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93758.56 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_1460338 |
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| Residue: | 809 |
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| Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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| BDBM50452692 |
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| n/a |
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| Name | BDBM50452692 |
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| Synonyms: | CHEMBL4204554 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19FN4O4S |
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| Mol. Mass. | 394.421 |
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| SMILES | Cc1nc(N)cc(OC2CCN(CC2)C(=O)c2ccc(cc2)S(F)(=O)=O)n1 |
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| Structure | 
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