| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Ligand | BDBM50452899 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1748714 (CHEMBL4183224) |
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| IC50 | 6760±n/a nM |
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| Citation |  Wang, K; Bao, L; Zhou, N; Zhang, J; Liao, M; Zheng, Z; Wang, Y; Liu, C; Wang, J; Wang, L; Wang, W; Liu, S; Liu, H Structural Modification of Natural Product Ganomycin I Leading to Discovery of a ?-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem61:3609-3625 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Synonyms: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMDH_PIG | HMG-CoA reductase | HMGCR | HMGR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97149.70 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_109835 |
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| Residue: | 885 |
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| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
QKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETDTSSRPTFVVGNS
TLDSSLELEMQEPEIQIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTPVVRFPRACDSA
EVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKG
TEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKT
TTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEA
SGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVC
GTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
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| BDBM50452899 |
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| n/a |
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| Name | BDBM50452899 |
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| Synonyms: | CHEMBL4215012 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O3 |
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| Mol. Mass. | 326.4293 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6]-1=[#6]-[#6@@H](-[#8]-[#6]-1=O)-c1ccccc1-[#8] |r,t:11| |
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| Structure | 
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