| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropilin-1 |
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| Ligand | BDBM50453008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1748923 (CHEMBL4183433) |
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| Kd | 410±n/a nM |
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| Citation |  Powell, J; Mota, F; Steadman, D; Soudy, C; Miyauchi, JT; Crosby, S; Jarvis, A; Reisinger, T; Winfield, N; Evans, G; Finniear, A; Yelland, T; Chou, YT; Chan, AWE; O'Leary, A; Cheng, L; Liu, D; Fotinou, C; Milagre, C; Martin, JF; Jia, H; Frankel, P; Djordjevic, S; Tsirka, SE; Zachary, IC; Selwood, DL Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF?) Production in Regulatory T-Cells. J Med Chem61:4135-4154 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropilin-1 |
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| Name: | Neuropilin-1 |
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| Synonyms: | Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103122.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_617636 |
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| Residue: | 923 |
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| Sequence: | MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
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| BDBM50453008 |
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| n/a |
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| Name | BDBM50453008 |
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| Synonyms: | CHEMBL4205347 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32N6O6S2 |
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| Mol. Mass. | 648.752 |
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| SMILES | NC(=N)NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cc(cc2CCOc12)-c1cccc(Cc2ccccn2)c1)C(O)=O |r| |
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| Structure | 
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