| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2A |
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| Ligand | BDBM50453949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1751672 (CHEMBL4186432) |
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| Kd | >10000±n/a nM |
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| Citation |  Lai, KW; Romero, FA; Tsui, V; Beresini, MH; de Leon Boenig, G; Bronner, SM; Chen, K; Chen, Z; Choo, EF; Crawford, TD; Cyr, P; Kaufman, S; Li, Y; Liao, J; Liu, W; Ly, J; Murray, J; Shen, W; Wai, J; Wang, F; Zhu, C; Zhu, X; Magnuson, S Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. Bioorg Med Chem Lett28:15-23 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT2A |
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| Name: | Histone acetyltransferase KAT2A |
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| Synonyms: | GCN5 | GCN5 | GCN5L2 | General control of amino acid synthesis protein 5-like 2 | HGCN5 | Histone acetyltransferase GCN5 | Histone acetyltransferase KAT2A | Histone acetyltransferase KAT2A/KAT2B | HsGCN5 | KAT2A | KAT2A_HUMAN | Lysine acetyltransferase 2A | STAF97 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93956.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_100876 |
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| Residue: | 837 |
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| Sequence: | MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
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| BDBM50453949 |
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| n/a |
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| Name | BDBM50453949 |
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| Synonyms: | CHEMBL4208820 | US11247989, Example 87 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O3 |
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| Mol. Mass. | 510.5869 |
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| SMILES | CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1 |
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| Structure | 
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