| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50454320 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1752599 (CHEMBL4187359) |
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| Ki | 22900±n/a nM |
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| Citation |  Li, ZP; Song, YH; Uddin, Z; Wang, Y; Park, KH Inhibition of protein tyrosine phosphatase 1B (PTP1B) and ?-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization. Bioorg Med Chem26:737-746 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50454320 |
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| n/a |
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| Name | BDBM50454320 |
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| Synonyms: | CHEMBL4217516 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28O7 |
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| Mol. Mass. | 428.4749 |
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| SMILES | [#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#6]-[#6]C([#6])([#6])[#8])c(-[#8])c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6] |
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| Structure | 
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