Reaction Details |
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Target | Elongin-C |
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Ligand | BDBM50459948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1767769 (CHEMBL4219881) |
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Kd | 350±n/a nM |
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Citation | Soares, P; Gadd, MS; Frost, J; Galdeano, C; Ellis, L; Epemolu, O; Rocha, S; Read, KD; Ciulli, A Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli J Med Chem61:599-618 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Elongin-C |
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Name: | Elongin-C |
Synonyms: | ELOC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin-C | RNA polymerase II transcription factor SIII subunit C | SIII p15 | TCEB1 | Transcription elongation factor B polypeptide 1 |
Type: | PROTEIN |
Mol. Mass.: | 12466.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_108414 |
Residue: | 112 |
Sequence: | MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEV
NFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
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BDBM50459948 |
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n/a |
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Name | BDBM50459948 |
Synonyms: | CHEMBL4228328 | US10730870, Example 12 | US11512083, Example 12 |
Type | Small organic molecule |
Emp. Form. | C25H34N4O4S |
Mol. Mass. | 486.627 |
SMILES | CCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r| |
Structure |
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