| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 2 |
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| Ligand | BDBM50460168 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1768944 (CHEMBL4221056) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kojima, T; Mochizuki, M; Takai, T; Hoashi, Y; Morimoto, S; Seto, M; Nakamura, M; Kobayashi, K; Sako, Y; Tanaka, M; Kanzaki, N; Kosugi, Y; Yano, T; Aso, K Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists. Bioorg Med Chem26:2229-2250 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 2 |
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| Name: | Corticotropin-releasing factor receptor 2 |
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| Synonyms: | CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 47694.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13324 |
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| Residue: | 411 |
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| Sequence: | MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
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| BDBM50460168 |
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| n/a |
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| Name | BDBM50460168 |
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| Synonyms: | CHEMBL4225709 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19ClF5N5O2 |
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| Mol. Mass. | 491.842 |
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| SMILES | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c32)c(C)n1 |r| |
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| Structure | 
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