Ki Summary

Reaction Details

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Target

Toll-like receptor 2

Ligand

BDBM50461185

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1770812 (CHEMBL4222924)

IC50

4651±n/a nM

Citation

Arai, Y; Inuki, S; Fujimoto, Y Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity. Bioorg Med Chem Lett28:1638-1641 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 2

Name:

Toll-like receptor 2

Synonyms:

TIL4 | TLR2 | TLR2_HUMAN | Toll-like receptor 2 | Toll-like receptor 2 (TLR2)

Type:

Protein

Mol. Mass.:

89837.58

Organism:

Homo sapiens (Human)

Description:

O60603

Residue:

784

Sequence:

MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS

BDBM50461185

n/a

Name

BDBM50461185

Synonyms:

CHEMBL4225148

Type

Small organic molecule

Emp. Form.

C64H123N11O13S

Mol. Mass.

1286.792

SMILES

CCCCCCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)OC(=O)CCCCNC(=O)CCCCCCCCC |r|

Structure