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TargetSterol O-acyltransferase 2
LigandBDBM50360305
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1771371 (CHEMBL4223483)
IC50 3100±n/a nM
Citation Kapojos, MM; Abdjul, DB; Yamazaki, H; Ohshiro, T; Rotinsulu, H; Wewengkang, DS; Sumilat, DA; Tomoda, H; Namikoshi, M; Uchida, R Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. Bioorg Med Chem Lett28:1911-1914 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sterol O-acyltransferase 2
Name:Sterol O-acyltransferase 2
Synonyms:ACAT-2 | ACAT2 | Acyl-coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | SOAT2 | SOAT2_CHLAE | Sterol O-acyltransferase 2
Type:PROTEIN
Mol. Mass.:60426.29
Organism:Chlorocebus aethiops
Description:ChEMBL_116979
Residue:526
Sequence:
MEPGGARLRLQRTEGPGGEREHQPCRDGNTETHRAPDLVKWTRHMEAVKAQLLEQAQGQL
RELLDRAMWEAIQSYPSQDKPPPLPPPDSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARPGARGTWTLGAGLGCALLAAHALVLCALPVHVAVEHQLPPASRCVLVFEQ
VRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYIRWNY
VAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFF
AFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGA
QARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQHTGPAWNVL
MWTMLFLGQGIQVSLYCQEWYARRHCPLPQTTFWGLVTPRSWSCHT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360305
n/a
NameBDBM50360305
Synonyms:CHEMBL409855 | US9149492, Beauveriolide III
TypeSmall organic molecule
Emp. Form.C27H41N3O5
Mol. Mass.487.6315
SMILESCCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r|
Structure
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