| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50461446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771367 (CHEMBL4223479) |
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| IC50 | 780±n/a nM |
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| Citation |  Kapojos, MM; Abdjul, DB; Yamazaki, H; Ohshiro, T; Rotinsulu, H; Wewengkang, DS; Sumilat, DA; Tomoda, H; Namikoshi, M; Uchida, R Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. Bioorg Med Chem Lett28:1911-1914 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | ACAT1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1 | SOAT1_CHLAE | Sterol O-acyltransferase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64744.47 |
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| Organism: | Chlorocebus aethiops |
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| Description: | ChEMBL_116975 |
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| Residue: | 550 |
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| Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRKPAKESLEAPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQRWATGYSKSSHPLINSLFHGFLFMVFQIGILGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMQFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVMMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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| BDBM50461446 |
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| n/a |
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| Name | BDBM50461446 |
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| Synonyms: | CHEMBL4227742 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H26Cl6N2O2 |
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| Mol. Mass. | 491.108 |
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| SMILES | CCC(=O)[C@H](C[C@H](C)C(Cl)(Cl)Cl)NC(=O)[C@H](C[C@H](C)C(Cl)(Cl)Cl)N(C)C |r| |
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| Structure | 
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