Reaction Details |
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Target | Histone acetyltransferase KAT2A |
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Ligand | BDBM50158627 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1771652 (CHEMBL4223764) |
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IC50 | >80000±n/a nM |
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Citation | Bennett, MJ; Wu, Y; Boloor, A; Matuszkiewicz, J; O'Connell, SM; Shi, L; Stansfield, RK; Del Rosario, JR; Veal, JM; Hosfield, DJ; Xu, J; Kaldor, SW; Stafford, JA; Betancort, JM Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors. Bioorg Med Chem Lett28:1811-1816 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone acetyltransferase KAT2A |
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Name: | Histone acetyltransferase KAT2A |
Synonyms: | GCN5 | GCN5 | GCN5L2 | General control of amino acid synthesis protein 5-like 2 | HGCN5 | Histone acetyltransferase GCN5 | Histone acetyltransferase KAT2A | Histone acetyltransferase KAT2A/KAT2B | HsGCN5 | KAT2A | KAT2A_HUMAN | Lysine acetyltransferase 2A | STAF97 |
Type: | PROTEIN |
Mol. Mass.: | 93956.22 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_100876 |
Residue: | 837 |
Sequence: | MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
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BDBM50158627 |
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n/a |
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Name | BDBM50158627 |
Synonyms: | CHEMBL3787482 | US10023592, Example 81 |
Type | Small organic molecule |
Emp. Form. | C24H25N3O4S |
Mol. Mass. | 451.538 |
SMILES | CCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC |
Structure |
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