Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50069900 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1776208 (CHEMBL4233200) |
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IC50 | 25±n/a nM |
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Citation | Shibuya, K; Kawamine, K; Miura, T; Ozaki, C; Edano, T; Mizuno, K; Yoshinaka, Y; Tsunenari, Y Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors. Bioorg Med Chem26:4001-4013 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT |
Type: | Multi-pass membrane protein may form homo- or heterodimers. |
Mol. Mass.: | 64751.94 |
Organism: | Homo sapiens (Human) |
Description: | P35610 |
Residue: | 550 |
Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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BDBM50069900 |
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n/a |
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Name | BDBM50069900 |
Synonyms: | 2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate | AVASIMIBE | CHEMBL101309 | CI-1011 | [2-(2,4,6-Triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester |
Type | Small organic molecule |
Emp. Form. | C29H43NO4S |
Mol. Mass. | 501.721 |
SMILES | CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C |
Structure |
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