| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50005944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1776184 (CHEMBL4233176) |
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| IC50 | 310±n/a nM |
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| Citation |  Shibuya, K; Kawamine, K; Miura, T; Ozaki, C; Edano, T; Mizuno, K; Yoshinaka, Y; Tsunenari, Y Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors. Bioorg Med Chem26:4001-4013 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63818.83 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_90523 |
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| Residue: | 540 |
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| Sequence: | MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVG
CHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLD
ELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWA
MFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPP
ASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRD
NYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI
LPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYY
YVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIV
NDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
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| BDBM50005944 |
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| n/a |
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| Name | BDBM50005944 |
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| Synonyms: | 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide | CHEMBL22373 | CI-976 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H39NO4 |
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| Mol. Mass. | 393.5601 |
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| SMILES | CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC |
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| Structure | 
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