Reaction Details |
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Target | Dopamine beta-hydroxylase |
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Ligand | BDBM50014968 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_59140 |
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pH | 4.5±n/a |
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Ki | 55±n/a nM |
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Comments | extracted |
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Citation | Kruse, LI; Kaiser, C; DeWolf, WE; Frazee, JS; Erickson, RW; Ezekiel, M; Ohlstein, EH; Ruffolo, RR; Berkowitz, BA Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase. J Med Chem29:887-9 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dopamine beta-hydroxylase |
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Name: | Dopamine beta-hydroxylase |
Synonyms: | DBH | DOPO_BOVIN |
Type: | PROTEIN |
Mol. Mass.: | 68136.39 |
Organism: | Bos taurus |
Description: | ChEMBL_50738 |
Residue: | 610 |
Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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BDBM50014968 |
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n/a |
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Name | BDBM50014968 |
Synonyms: | 1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione | 4-(2-Mercapto-imidazol-1-ylmethyl)-phenol | CHEMBL164747 |
Type | Small organic molecule |
Emp. Form. | C10H10N2OS |
Mol. Mass. | 206.264 |
SMILES | Oc1ccc(Cn2cc[nH]c2=S)cc1 |
Structure |
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