| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50014983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_59140 |
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| pH | 4.5±n/a |
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| Ki | 41±n/a nM |
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| Comments | extracted |
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| Citation |  Kruse, LI; Kaiser, C; DeWolf, WE; Frazee, JS; Erickson, RW; Ezekiel, M; Ohlstein, EH; Ruffolo, RR; Berkowitz, BA Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase. J Med Chem29:887-9 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68136.39 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_50738 |
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| Residue: | 610 |
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| Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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| BDBM50014983 |
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| n/a |
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| Name | BDBM50014983 |
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| Synonyms: | 1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-thione | CHEMBL278068 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8F2N2S |
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| Mol. Mass. | 226.246 |
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| SMILES | Fc1cc(F)cc(Cn2cc[nH]c2=S)c1 |
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| Structure | 
|
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