| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 4 |
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| Ligand | BDBM50465777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1788748 (CHEMBL4260482) |
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| EC50 | 160±n/a nM |
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| Citation |  Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y Novel K Bioorg Med Chem Lett28:3793-3797 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 4 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 4 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77131.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1520985 |
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| Residue: | 695 |
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| Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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| BDBM50465777 |
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| n/a |
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| Name | BDBM50465777 |
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| Synonyms: | CHEMBL4288707 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F2NO4S |
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| Mol. Mass. | 431.452 |
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| SMILES | C[C@H](NC(=O)c1cc(F)c(F)cc1Oc1ccccc1)c1cccc(c1)S(C)(=O)=O |r| |
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| Structure | 
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