| Reaction Details |
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 | Report a problem with these data |
| Target | Alcohol dehydrogenase class-3 |
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| Ligand | BDBM50465805 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1788804 (CHEMBL4260538) |
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| IC50 | 9.2±n/a nM |
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| Citation |  Muthukaman, N; Deshmukh, S; Tondlekar, S; Tambe, M; Pisal, D; Sarode, N; Mhatre, S; Chakraborti, S; Shah, D; Bhosale, VM; Kulkarni, A; Mahat, MYA; Jadhav, SB; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett28:3766-3773 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alcohol dehydrogenase class-3 |
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| Name: | Alcohol dehydrogenase class-3 |
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| Synonyms: | 1.1.1.- | 1.1.1.1 | 1.1.1.284 | ADH5 | ADHX | ADHX_HUMAN | Alcohol dehydrogenase 5 | Alcohol dehydrogenase class chi chain | Alcohol dehydrogenase class-3 | Alcohol dehydrogenase class-III | FALDH | FDH | Glutathione-dependent formaldehyde dehydrogenase (GSH-FDH) | S-nitrosoglutathione reductase (GSNOR) | alcohol dehydrogenase 3 (ADH-3) |
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| Type: | n/a |
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| Mol. Mass.: | 39728.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11766 |
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| Residue: | 374 |
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| Sequence: | MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI
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| BDBM50465805 |
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| n/a |
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| Name | BDBM50465805 |
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| Synonyms: | CHEMBL4290485 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11ClN6 |
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| Mol. Mass. | 322.752 |
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| SMILES | Clc1cc(ccc1-c1ccc(cc1)-n1ccnc1)-c1nnn[nH]1 |
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| Structure | 
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