Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130865 (CHEMBL3634853) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130760 (CHEMBL3634855) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50048260 (CHEMBL3315045) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay | Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130759 (CHEMBL3634854) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM31592 (PF-2545920 | US9138494, MP-10 | substituted pyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... | Bioorg Med Chem Lett 24: 2073-8 (2014) Article DOI: 10.1016/j.bmcl.2014.03.054 BindingDB Entry DOI: 10.7270/Q22V2HNB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130761 (CHEMBL3634856) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM363753 (US9855229, Compound 7) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.615 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research | Assay Description The assay is based on the principle that binding of the agonist to the RORγ causes a conformational change around helix 12 in the ligand binding... | J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q20867MM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130763 (CHEMBL3634858) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM50048260 (CHEMBL3315045) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of rat recombinant GST-tagged PDE10A using [3H]-cAMP as substrate by scintillation proximity assay | Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50494753 (CHEMBL3094144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay | Bioorg Med Chem Lett 23: 6747-54 (2013) Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130850 (CHEMBL3634746) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130849 (CHEMBL3634744) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Mus musculus) | BDBM50048260 (CHEMBL3315045) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay | Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130853 (CHEMBL3634748) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130860 (CHEMBL3634847) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50048261 (CHEMBL3315044) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay | Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130854 (CHEMBL3634749) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM31596 (substituted pyrazole, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... | Bioorg Med Chem Lett 24: 2073-8 (2014) Article DOI: 10.1016/j.bmcl.2014.03.054 BindingDB Entry DOI: 10.7270/Q22V2HNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191653 (US9186360, 57) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.45 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130841 (CHEMBL3634745) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM60874 (US9186360, 62) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.68 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130762 (CHEMBL3634857) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130858 (CHEMBL3634845) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130856 (CHEMBL3634751) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50227631 (2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of human recombinant mPGES-1 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 incubated for 10 mins followed by ... | Bioorg Med Chem Lett 26: 5977-5984 (2016) Article DOI: 10.1016/j.bmcl.2016.10.079 BindingDB Entry DOI: 10.7270/Q2XK8HJ8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50227631 (2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation using PGH2 a substrate preincubated for 10 min... | Bioorg Med Chem Lett 27: 2594-2601 (2017) Article DOI: 10.1016/j.bmcl.2017.03.068 BindingDB Entry DOI: 10.7270/Q24B33Q3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM363754 (US9855229, Compound 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.98 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research | Assay Description The assay is based on the principle that binding of the agonist to the RORγ causes a conformational change around helix 12 in the ligand binding... | J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q20867MM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191709 (US9186360, 55) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.15 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM363752 (US9855229, Compound 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research | Assay Description The assay is based on the principle that binding of the agonist to the RORγ causes a conformational change around helix 12 in the ligand binding... | J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q20867MM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50452066 (CHEMBL4206145) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured ... | Bioorg Med Chem Lett 27: 5131-5138 (2017) Article DOI: 10.1016/j.bmcl.2017.10.062 BindingDB Entry DOI: 10.7270/Q2JS9T0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191712 (US9186360, 59) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.21 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50452084 (CHEMBL4207228) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured ... | Bioorg Med Chem Lett 27: 5131-5138 (2017) Article DOI: 10.1016/j.bmcl.2017.10.062 BindingDB Entry DOI: 10.7270/Q2JS9T0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191652 (US9186360, 51 | US9186360, 52) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.49 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50048258 (CHEMBL3315046) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay | Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50207335 (CHEMBL3961834) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Mus musculus) | BDBM50130841 (CHEMBL3634745) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of mouse PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity as... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50130851 (CHEMBL3634747) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... | J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50452071 (CHEMBL4208718) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured ... | Bioorg Med Chem Lett 27: 5131-5138 (2017) Article DOI: 10.1016/j.bmcl.2017.10.062 BindingDB Entry DOI: 10.7270/Q2JS9T0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191713 (US9186360, 61) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.93 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human)) | BDBM50397056 (CHEMBL2171440) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay | Bioorg Med Chem Lett 22: 6286-91 (2012) Article DOI: 10.1016/j.bmcl.2012.07.077 BindingDB Entry DOI: 10.7270/Q21Z45JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460527 (CHEMBL4228430) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460529 (CHEMBL4228804) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM124296 (US8759537, 33) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 using PGH2 as substrate pretreated for 25 mins followed by substrate addition measured after 60 secs by HTRF a... | Bioorg Med Chem Lett 27: 5131-5138 (2017) Article DOI: 10.1016/j.bmcl.2017.10.062 BindingDB Entry DOI: 10.7270/Q2JS9T0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460540 (CHEMBL4227388) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460542 (CHEMBL4227545) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM191722 (US9186360, 71) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.18 | n/a | n/a | n/a | n/a | n/a | 25 |
GLENMARK PHARMACEUTICALS S.A. US Patent | Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ... | US Patent US9186360 (2015) BindingDB Entry DOI: 10.7270/Q2TX3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460537 (CHEMBL4226536) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50207335 (CHEMBL3961834) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of human recombinant mPGES-1 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 incubated for 10 mins followed by ... | Bioorg Med Chem Lett 26: 5977-5984 (2016) Article DOI: 10.1016/j.bmcl.2016.10.079 BindingDB Entry DOI: 10.7270/Q2XK8HJ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50460531 (CHEMBL4226545) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM50207335 (CHEMBL3961834) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ... | Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5 | |||||||||||
More data for this Ligand-Target Pair |
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