Reaction Details |
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Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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Ligand | BDBM50048260 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1458264 (CHEMBL3368979) |
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IC50 | 1.2±n/a nM |
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Citation | Das, S; Shelke, DE; Harde, RL; Avhad, VB; Khairatkar-Joshi, N; Gullapalli, S; Gupta, PK; Gandhi, MN; Bhateja, DK; Bajpai, M; Joshi, AA; Marathe, MY; Gudi, GS; Jadhav, SB; Mahat, MY; Thomas, A Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II. Bioorg Med Chem Lett24:3238-42 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Synonyms: | PDE10_MOUSE | Pde10a |
Type: | PROTEIN |
Mol. Mass.: | 89407.64 |
Organism: | Mus musculus |
Description: | ChEMBL_1458264 |
Residue: | 790 |
Sequence: | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
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BDBM50048260 |
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n/a |
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Name | BDBM50048260 |
Synonyms: | CHEMBL3315045 |
Type | Small organic molecule |
Emp. Form. | C25H20N4O |
Mol. Mass. | 392.4525 |
SMILES | Cc1cnc2c(cn(C)c2c1)-c1ccc(Oc2ncccc2-c2ccncc2)cc1 |
Structure |
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