Found 156 hits with Last Name = 'gullapalli' and Initial = 's' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130865
(CHEMBL3634853)Show SMILES O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C25H19N3O2/c29-24-13-11-21(25(28-24)18-4-2-1-3-5-18)17-6-9-20(10-7-17)30-16-19-8-12-22-23(27-19)14-15-26-22/h1-15,26H,16H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50048260
(CHEMBL3315045)Show SMILES Cc1cnc2c(cn(C)c2c1)-c1ccc(Oc2ncccc2-c2ccncc2)cc1 Show InChI InChI=1S/C25H20N4O/c1-17-14-23-24(28-15-17)22(16-29(23)2)18-5-7-20(8-6-18)30-25-21(4-3-11-27-25)19-9-12-26-13-10-19/h3-16H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130760
(CHEMBL3634855)Show SMILES Clc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3[nH]ccc3n2)cc1 Show InChI InChI=1S/C25H18ClN3O2/c26-18-5-1-17(2-6-18)25-21(10-12-24(30)29-25)16-3-8-20(9-4-16)31-15-19-7-11-22-23(28-19)13-14-27-22/h1-14,27H,15H2,(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130759
(CHEMBL3634854)Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3[nH]ccc3n2)cc1 Show InChI InChI=1S/C25H18FN3O2/c26-18-5-1-17(2-6-18)25-21(10-12-24(30)29-25)16-3-8-20(9-4-16)31-15-19-7-11-22-23(28-19)13-14-27-22/h1-14,27H,15H2,(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130761
(CHEMBL3634856)Show SMILES O=c1ccc(-c2ccc(OCc3ccc4[nH]ccc4n3)cc2)c([nH]1)-c1ccncc1 Show InChI InChI=1S/C24H18N4O2/c29-23-8-6-20(24(28-23)17-9-12-25-13-10-17)16-1-4-19(5-2-16)30-15-18-3-7-21-22(27-18)11-14-26-21/h1-14,26H,15H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130763
(CHEMBL3634858)Show SMILES Cn1ccc2nc(COc3ccc(cc3)-c3ccc(=O)[nH]c3-c3ccc(Cl)cc3)ccc12 Show InChI InChI=1S/C26H20ClN3O2/c1-30-15-14-23-24(30)12-8-20(28-23)16-32-21-9-4-17(5-10-21)22-11-13-25(31)29-26(22)18-2-6-19(27)7-3-18/h2-15H,16H2,1H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50048260
(CHEMBL3315045)Show SMILES Cc1cnc2c(cn(C)c2c1)-c1ccc(Oc2ncccc2-c2ccncc2)cc1 Show InChI InChI=1S/C25H20N4O/c1-17-14-23-24(28-15-17)22(16-29(23)2)18-5-7-20(8-6-18)30-25-21(4-3-11-27-25)19-9-12-26-13-10-19/h3-16H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged PDE10A using [3H]-cAMP as substrate by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494753
(CHEMBL3094144)Show SMILES Cc1nc(C)c(s1)-c1nc(C)c2sc3cc(OCc4ccc5ccccc5n4)ccc3n12 Show InChI InChI=1S/C25H20N4OS2/c1-14-23(31-16(3)26-14)24-27-15(2)25-29(24)21-11-10-19(12-22(21)32-25)30-13-18-9-8-17-6-4-5-7-20(17)28-18/h4-12H,13H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130850
(CHEMBL3634746)Show SMILES Clc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19ClN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130849
(CHEMBL3634744)Show SMILES O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C27H20N2O2/c30-26-17-16-24(27(29-26)21-7-2-1-3-8-21)19-11-14-23(15-12-19)31-18-22-13-10-20-6-4-5-9-25(20)28-22/h1-17H,18H2,(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50048260
(CHEMBL3315045)Show SMILES Cc1cnc2c(cn(C)c2c1)-c1ccc(Oc2ncccc2-c2ccncc2)cc1 Show InChI InChI=1S/C25H20N4O/c1-17-14-23-24(28-15-17)22(16-29(23)2)18-5-7-20(8-6-18)30-25-21(4-3-11-27-25)19-9-12-26-13-10-19/h3-16H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130860
(CHEMBL3634847)Show SMILES O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c([nH]1)-c1ccncc1 Show InChI InChI=1S/C26H19N3O2/c30-25-12-11-23(26(29-25)20-13-15-27-16-14-20)18-6-9-22(10-7-18)31-17-21-8-5-19-3-1-2-4-24(19)28-21/h1-16H,17H2,(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130853
(CHEMBL3634748)Show SMILES Fc1cccc(c1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-21-6-3-5-20(16-21)27-24(14-15-26(31)30-27)18-9-12-23(13-10-18)32-17-22-11-8-19-4-1-2-7-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381287
(CHEMBL2019020)Show SMILES COc1cc(N)ccc1-c1nc2n(C)nc(C3CCCCC3)c2c(=O)[nH]1 Show InChI InChI=1S/C19H23N5O2/c1-24-18-15(16(23-24)11-6-4-3-5-7-11)19(25)22-17(21-18)13-9-8-12(20)10-14(13)26-2/h8-11H,3-7,20H2,1-2H3,(H,21,22,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50048261
(CHEMBL3315044)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc12 Show InChI InChI=1S/C24H18N4O/c1-28-16-21(23-22(28)5-3-12-26-23)17-6-8-19(9-7-17)29-24-20(4-2-13-27-24)18-10-14-25-15-11-18/h2-16H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130854
(CHEMBL3634749)Show SMILES Fc1ccc(c(F)c1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H18F2N2O2/c28-19-8-12-23(24(29)15-19)27-22(13-14-26(32)31-27)17-6-10-21(11-7-17)33-16-20-9-5-18-3-1-2-4-25(18)30-20/h1-15H,16H2,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130841
(CHEMBL3634745)Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130762
(CHEMBL3634857)Show SMILES Cn1ccc2nc(COc3ccc(cc3)-c3ccc(=O)[nH]c3-c3ccc(F)cc3)ccc12 Show InChI InChI=1S/C26H20FN3O2/c1-30-15-14-23-24(30)12-8-20(28-23)16-32-21-9-4-17(5-10-21)22-11-13-25(31)29-26(22)18-2-6-19(27)7-3-18/h2-15H,16H2,1H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130856
(CHEMBL3634751)Show SMILES Cc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C28H22N2O2/c1-19-6-8-22(9-7-19)28-25(16-17-27(31)30-28)20-11-14-24(15-12-20)32-18-23-13-10-21-4-2-3-5-26(21)29-23/h2-17H,18H2,1H3,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130858
(CHEMBL3634845)Show SMILES COc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C28H22N2O3/c1-32-23-12-9-21(10-13-23)28-25(16-17-27(31)30-28)19-7-14-24(15-8-19)33-18-22-11-6-20-4-2-3-5-26(20)29-22/h2-17H,18H2,1H3,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50130841
(CHEMBL3634745)Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of mouse PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity as... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50048258
(CHEMBL3315046)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc12 Show InChI InChI=1S/C24H17ClN4O/c1-29-15-21(23-22(29)13-18(25)14-28-23)16-4-6-19(7-5-16)30-24-20(3-2-10-27-24)17-8-11-26-12-9-17/h2-15H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130851
(CHEMBL3634747)Show SMILES Fc1ccccc1-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-24-7-3-2-6-23(24)27-22(15-16-26(31)30-27)18-10-13-21(14-11-18)32-17-20-12-9-19-5-1-4-8-25(19)29-20/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50397056
(CHEMBL2171440)Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)C1CC1C(N)=O Show InChI InChI=1S/C23H27N5O3/c1-12-19-20(23(30)28(27-12)14-6-4-3-5-7-14)26-22(25-19)15-9-8-13(10-18(15)31-2)16-11-17(16)21(24)29/h8-10,14,16-17H,3-7,11H2,1-2H3,(H2,24,29)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay |
Bioorg Med Chem Lett 22: 6286-91 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.077 BindingDB Entry DOI: 10.7270/Q21Z45JB |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130840
(CHEMBL3634865)Show SMILES O=c1ccc(-c2ccncc2)c([nH]1)-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C26H19N3O2/c30-25-12-11-23(18-13-15-27-16-14-18)26(29-25)20-6-9-22(10-7-20)31-17-21-8-5-19-3-1-2-4-24(19)28-21/h1-16H,17H2,(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381291
(CHEMBL2019104)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCCNCC1 Show InChI InChI=1S/C23H29N5O2S/c1-30-18-14-16(28-12-5-10-24-11-13-28)8-9-17(18)21-25-22(29)19-20(27-31-23(19)26-21)15-6-3-2-4-7-15/h8-9,14-15,24H,2-7,10-13H2,1H3,(H,25,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50048261
(CHEMBL3315044)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc12 Show InChI InChI=1S/C24H18N4O/c1-28-16-21(23-22(28)5-3-12-26-23)17-6-8-19(9-7-17)29-24-20(4-2-13-27-24)18-10-14-25-15-11-18/h2-16H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50130841
(CHEMBL3634745)Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of rat PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity assa... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494759
(CHEMBL3094141)Show SMILES Cc1nc(-c2ccncc2)n2c3ccc(OCc4ccc5ccccc5n4)cc3sc12 Show InChI InChI=1S/C25H18N4OS/c1-16-25-29(24(27-16)18-10-12-26-13-11-18)22-9-8-20(14-23(22)31-25)30-15-19-7-6-17-4-2-3-5-21(17)28-19/h2-14H,15H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130855
(CHEMBL3634750)Show SMILES Cc1ccccc1-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C28H22N2O2/c1-19-6-2-4-8-24(19)28-25(16-17-27(31)30-28)20-11-14-23(15-12-20)32-18-22-13-10-21-7-3-5-9-26(21)29-22/h2-17H,18H2,1H3,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494752
(CHEMBL3094147)Show SMILES [H][C@]12C[C@]1(COC2)c1nc(C)c2sc3cc(OCc4ccc5ccccc5n4)ccc3n12 |r| Show InChI InChI=1S/C25H21N3O2S/c1-15-23-28(24(26-15)25-11-17(25)12-29-14-25)21-9-8-19(10-22(21)31-23)30-13-18-7-6-16-4-2-3-5-20(16)27-18/h2-10,17H,11-14H2,1H3/t17-,25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50048261
(CHEMBL3315044)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc12 Show InChI InChI=1S/C24H18N4O/c1-28-16-21(23-22(28)5-3-12-26-23)17-6-8-19(9-7-17)29-24-20(4-2-13-27-24)18-10-14-25-15-11-18/h2-16H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged PDE10A using [3H]-cAMP as substrate by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50048262
(CHEMBL3315042)Show SMILES Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2ncccc12 Show InChI InChI=1S/C23H17N5O/c1-28-15-19(22-20(28)3-2-10-25-22)16-4-6-18(7-5-16)29-23-21(26-13-14-27-23)17-8-11-24-12-9-17/h2-15H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50130857
(CHEMBL3634752)Show SMILES FC(F)(F)c1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C28H19F3N2O2/c29-28(30,31)21-10-5-20(6-11-21)27-24(15-16-26(34)33-27)18-8-13-23(14-9-18)35-17-22-12-7-19-3-1-2-4-25(19)32-22/h1-16H,17H2,(H,33,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ... |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494757
(CHEMBL3094139)Show SMILES CC(=O)N1CC(C1)c1nc(C)c2sc3cc(OCc4ccc5ccccc5n4)ccc3n12 Show InChI InChI=1S/C25H22N4O2S/c1-15-25-29(24(26-15)18-12-28(13-18)16(2)30)22-10-9-20(11-23(22)32-25)31-14-19-8-7-17-5-3-4-6-21(17)27-19/h3-11,18H,12-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM50130841
(CHEMBL3634745)Show SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C27H19FN2O2/c28-21-10-5-20(6-11-21)27-24(15-16-26(31)30-27)18-8-13-23(14-9-18)32-17-22-12-7-19-3-1-2-4-25(19)29-22/h1-16H,17H2,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Research Centre
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT2b |
J Med Chem 58: 8292-308 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50048258
(CHEMBL3315046)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc12 Show InChI InChI=1S/C24H17ClN4O/c1-29-15-21(23-22(29)13-18(25)14-28-23)16-4-6-19(7-5-16)30-24-20(3-2-10-27-24)17-8-11-26-12-9-17/h2-15H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494748
(CHEMBL3094137)Show SMILES [H][C@@]12C[C@@]1(COC2)c1nc(C)c2sc3cc(OCc4ccc5ccccc5n4)ccc3n12 |r| Show InChI InChI=1S/C25H21N3O2S/c1-15-23-28(24(26-15)25-11-17(25)12-29-14-25)21-9-8-19(10-22(21)31-23)30-13-18-7-6-16-4-2-3-5-20(16)27-18/h2-10,17H,11-14H2,1H3/t17-,25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381296
(CHEMBL2019109)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCCC(O)CC1 Show InChI InChI=1S/C24H30N4O3S/c1-31-19-14-16(28-12-5-8-17(29)11-13-28)9-10-18(19)22-25-23(30)20-21(27-32-24(20)26-22)15-6-3-2-4-7-15/h9-10,14-15,17,29H,2-8,11-13H2,1H3,(H,25,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50048258
(CHEMBL3315046)Show SMILES Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc12 Show InChI InChI=1S/C24H17ClN4O/c1-29-15-21(23-22(29)13-18(25)14-28-23)16-4-6-19(7-5-16)30-24-20(3-2-10-27-24)17-8-11-26-12-9-17/h2-15H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged PDE10A using [3H]-cAMP as substrate by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494758
(CHEMBL3094145)Show SMILES Cc1nc(C2CCOCC2)n2c3ccc(OCc4ccc5ccccc5n4)cc3sc12 Show InChI InChI=1S/C25H23N3O2S/c1-16-25-28(24(26-16)18-10-12-29-13-11-18)22-9-8-20(14-23(22)31-25)30-15-19-7-6-17-4-2-3-5-21(17)27-19/h2-9,14,18H,10-13,15H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50381299
(CHEMBL2019112)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H29N5O3S/c1-15(30)28-10-12-29(13-11-28)17-8-9-18(19(14-17)32-2)22-25-23(31)20-21(27-33-24(20)26-22)16-6-4-3-5-7-16/h8-9,14,16H,3-7,10-13H2,1-2H3,(H,25,26,31) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7B |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381293
(CHEMBL2019106)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCC(N)CC1 Show InChI InChI=1S/C23H29N5O2S/c1-30-18-13-16(28-11-9-15(24)10-12-28)7-8-17(18)21-25-22(29)19-20(27-31-23(19)26-21)14-5-3-2-4-6-14/h7-8,13-15H,2-6,9-12,24H2,1H3,(H,25,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50048263
(CHEMBL3315039)Show SMILES Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2nc3ccccc3cc12 Show InChI InChI=1S/C27H19N5O/c1-32-17-22(26-24(32)16-20-4-2-3-5-23(20)31-26)18-6-8-21(9-7-18)33-27-25(29-14-15-30-27)19-10-12-28-13-11-19/h2-17H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay |
Bioorg Med Chem Lett 24: 3238-42 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494755
(CHEMBL3094142)Show SMILES Cc1nc(-c2ccnc(C)c2)n2c3ccc(OCc4ccc5ccccc5n4)cc3sc12 Show InChI InChI=1S/C26H20N4OS/c1-16-13-19(11-12-27-16)25-28-17(2)26-30(25)23-10-9-21(14-24(23)32-26)31-15-20-8-7-18-5-3-4-6-22(18)29-20/h3-14H,15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381290
(CHEMBL2019103)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCNCC1 Show InChI InChI=1S/C22H27N5O2S/c1-29-17-13-15(27-11-9-23-10-12-27)7-8-16(17)20-24-21(28)18-19(26-30-22(18)25-20)14-5-3-2-4-6-14/h7-8,13-14,23H,2-6,9-12H2,1H3,(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50494750
(CHEMBL3094140)Show SMILES CC(=O)N1CCC(CC1)c1nc(C)c2sc3cc(OCc4ccc5ccccc5n4)ccc3n12 Show InChI InChI=1S/C27H26N4O2S/c1-17-27-31(26(28-17)20-11-13-30(14-12-20)18(2)32)24-10-9-22(15-25(24)34-27)33-16-21-8-7-19-5-3-4-6-23(19)29-21/h3-10,15,20H,11-14,16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A using [3H]-cAMP/[3H]-cGMP as substrate after 30 mins by radiometric assay |
Bioorg Med Chem Lett 23: 6747-54 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.027 BindingDB Entry DOI: 10.7270/Q2RV0RP4 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50397053
(CHEMBL2171422)Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(N)CC1 Show InChI InChI=1S/C24H32N6O2/c1-15-21-22(24(31)30(28-15)17-6-4-3-5-7-17)27-23(26-21)19-9-8-18(14-20(19)32-2)29-12-10-16(25)11-13-29/h8-9,14,16-17H,3-7,10-13,25H2,1-2H3,(H,26,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assay |
Bioorg Med Chem Lett 22: 6286-91 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.077 BindingDB Entry DOI: 10.7270/Q21Z45JB |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50381295
(CHEMBL2019108)Show SMILES COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCC(O)CC1 Show InChI InChI=1S/C23H28N4O3S/c1-30-18-13-15(27-11-9-16(28)10-12-27)7-8-17(18)21-24-22(29)19-20(26-31-23(19)25-21)14-5-3-2-4-6-14/h7-8,13-14,16,28H,2-6,9-12H2,1H3,(H,24,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Displacement of [3H]-cAMP from human recombinant PDE7A |
Bioorg Med Chem Lett 22: 3223-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.025 BindingDB Entry DOI: 10.7270/Q2NP25F2 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50397052
(CHEMBL2171423)Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCNCC1 Show InChI InChI=1S/C24H32N6O2/c1-16-21-22(24(31)30(28-16)17-7-4-3-5-8-17)27-23(26-21)19-10-9-18(15-20(19)32-2)29-13-6-11-25-12-14-29/h9-10,15,17,25H,3-8,11-14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay |
Bioorg Med Chem Lett 22: 6286-91 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.077 BindingDB Entry DOI: 10.7270/Q21Z45JB |
More data for this Ligand-Target Pair | |