BindingDB PrimarySearch

Found 320 hits with Last Name = 'gupta' and Initial = 'pk'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24732 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6	-48.8	32	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24731 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9	-47.8	51	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24734 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	11	-47.3	60	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24746 ((2S)-6-amino-N-[(1S)-4-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	13	-46.8	73	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24739 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	19	-45.8	107	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24733 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	20	-45.7	112	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24735 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	26	-45.0	146	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24741 ((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	28	-44.8	154	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24736 (Capped tripeptide aldehyde inhibitor, 24 \| benzyl ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	40	-43.9	222	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24728 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	41	-43.9	231	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair				3D Structure (crystal)
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24744 ((2S)-N-[(1S)-5-amino-1-{[(2S)-5-carbamimidamido-1-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	44	-43.7	245	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24742 ((2S)-6-amino-2-[(2S)-5-amino-2-(1-phenylacetamido)...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	46	-43.6	255	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24737 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	49	-43.4	271	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24748 ((2S)-2-[(2S)-6-amino-2-(1-phenylacetamido)hexanami...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	53	-43.2	297	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24745 ((2S)-6-amino-N-[(1S)-4-carbamimidamido-1-{[(2S)-5-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	58	-43.0	325	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24738 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	81	-42.1	454	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24730 ((2S)-6-amino-2-[(2S)-6-amino-2-[(2E)-3-phenylprop-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	104	-41.5	580	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24743 ((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	111	-41.3	619	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24740 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	160	-40.3	891	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24747 ((2S)-6-amino-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	2.07E+3	-33.7	1.16E+4	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24749 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-1-(1H-indol-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.60E+3	-31.7	2.57E+4	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371616 ((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130865 (CHEMBL3634853) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130760 (CHEMBL3634855) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50048260 (CHEMBL3315045) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130759 (CHEMBL3634854) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545552 (CHEMBL4646742) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545560 (CHEMBL4634421) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545558 (CHEMBL4642748) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545563 (CHEMBL4636838) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130761 (CHEMBL3634856) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371523 ((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130763 (CHEMBL3634858) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545567 (CHEMBL4649638) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50048260 (CHEMBL3315045) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-tagged PDE10A using [3H]-cAMP as substrate by scintillation proximity assay				Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130849 (CHEMBL3634744) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130850 (CHEMBL3634746) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371635 ((R)-4-(2-(1H-1,2,3-Triazol-1-yl)-4-(trifluoromethy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130860 (CHEMBL3634847) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Mus musculus)	BDBM50048260 (CHEMBL3315045) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130853 (CHEMBL3634748) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50048261 (CHEMBL3315044) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 24: 3238-42 (2014) Article DOI: 10.1016/j.bmcl.2014.06.028 BindingDB Entry DOI: 10.7270/Q25D8TGJ
Glenmark Pharmaceuticals Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371776 ((R)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130854 (CHEMBL3634749) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50545554 (CHEMBL4635247) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371648 ((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130841 (CHEMBL3634745) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130762 (CHEMBL3634857) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371652 ((R)-4-(2-(2-methyloxazol-4-yl)-4-(trifluoromethyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020) Article DOI: 10.1021/acs.jmedchem.0c00361 BindingDB Entry DOI: 10.7270/Q2V69P5C
Lupin Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130858 (CHEMBL3634845) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) Article DOI: 10.1021/acs.jmedchem.5b01240 BindingDB Entry DOI: 10.7270/Q2833TVD
Glenmark Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair

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