Reaction Details |
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Target | Alcohol dehydrogenase class-3 |
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Ligand | BDBM50465829 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1788804 (CHEMBL4260538) |
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IC50 | 11±n/a nM |
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Citation | Muthukaman, N; Deshmukh, S; Tondlekar, S; Tambe, M; Pisal, D; Sarode, N; Mhatre, S; Chakraborti, S; Shah, D; Bhosale, VM; Kulkarni, A; Mahat, MYA; Jadhav, SB; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett28:3766-3773 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alcohol dehydrogenase class-3 |
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Name: | Alcohol dehydrogenase class-3 |
Synonyms: | 1.1.1.- | 1.1.1.1 | 1.1.1.284 | ADH5 | ADHX | ADHX_HUMAN | Alcohol dehydrogenase 5 | Alcohol dehydrogenase class chi chain | Alcohol dehydrogenase class-3 | Alcohol dehydrogenase class-III | FALDH | FDH | Glutathione-dependent formaldehyde dehydrogenase (GSH-FDH) | S-nitrosoglutathione reductase (GSNOR) | alcohol dehydrogenase 3 (ADH-3) |
Type: | n/a |
Mol. Mass.: | 39728.34 |
Organism: | Homo sapiens (Human) |
Description: | P11766 |
Residue: | 374 |
Sequence: | MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI
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BDBM50465829 |
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n/a |
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Name | BDBM50465829 |
Synonyms: | CHEMBL4289979 |
Type | Small organic molecule |
Emp. Form. | C18H15FN6 |
Mol. Mass. | 334.3503 |
SMILES | CCc1cc(ccc1-c1ccc(cc1F)-c1nnn[nH]1)-n1ccnc1 |
Structure |
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