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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(1A) dopamine receptor | ||
| Ligand | BDBM50465945 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1789226 (CHEMBL4260960) | ||
| Ki | 6.8±n/a nM | ||
| Citation |  Davoren, JE; Nason, D; Coe, J; Dlugolenski, K; Helal, C; Harris, AR; LaChapelle, E; Liang, S; Liu, Y; O'Connor, R; Orozco, CC; Rai, BK; Salafia, M; Samas, B; Xu, W; Kozak, R; Gray, D Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem61:11384-11397 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(1A) dopamine receptor | |||
| Name: | D(1A) dopamine receptor | ||
| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49303.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21728 | ||
| Residue: | 446 | ||
| Sequence: |
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| BDBM50465945 | |||
| n/a | |||
| Name | BDBM50465945 | ||
| Synonyms: | CHEMBL4279267 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H17N3O2 | ||
| Mol. Mass. | 355.3893 | ||
| SMILES | Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C |(71.15,-35.83,;71.14,-34.29,;72.47,-33.52,;72.46,-31.97,;71.11,-31.22,;70.79,-29.72,;69.26,-29.56,;68.64,-30.97,;69.79,-31.99,;69.81,-33.53,;68.49,-34.3,;68.49,-35.85,;67.16,-36.62,;65.83,-35.85,;64.5,-36.63,;64.5,-38.17,;65.83,-38.93,;65.84,-40.47,;64.51,-41.24,;63.17,-40.47,;61.71,-40.95,;60.8,-39.72,;61.7,-38.47,;63.17,-38.94,;65.82,-34.31,;67.14,-33.54,;67.13,-32,)| | ||
| Structure | 
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