Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 5 |
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Ligand | BDBM50466038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1789678 (CHEMBL4261412) |
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IC50 | 37±n/a nM |
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Citation | Li, Y; Xiong, Y; Zhang, G; Zhang, L; Yang, W; Yang, J; Huang, L; Qiao, Z; Miao, Z; Lin, G; Sun, Q; Niu, T; Chen, L; Niu, D; Li, L; Yang, S Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem61:11398-11414 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 5 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 5 |
Synonyms: | 2.7.11.1 | KHS | Kinase homologous to SPS1/STE20 | M4K5_HUMAN | MAP4K5 | MAPK/ERK kinase kinase kinase 5 | MEK kinase kinase 5 | MEKKK 5 |
Type: | PROTEIN |
Mol. Mass.: | 95039.51 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1495741 |
Residue: | 846 |
Sequence: | MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
GHENSY
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BDBM50466038 |
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n/a |
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Name | BDBM50466038 |
Synonyms: | CHEMBL4281823 |
Type | Small organic molecule |
Emp. Form. | C25H22F3N5O2 |
Mol. Mass. | 481.4697 |
SMILES | CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12 |
Structure |
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