| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase YopH |
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| Ligand | BDBM50466475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793233 (CHEMBL4265152) |
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| IC50 | 7100±n/a nM |
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| Citation |  Sens, L; de Souza, ACA; Pacheco, LA; Menegatti, ACO; Mori, M; Mascarello, A; Nunes, RJ; Terenzi, H Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors. Bioorg Med Chem26:5742-5750 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase YopH |
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| Name: | Tyrosine-protein phosphatase YopH |
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| Synonyms: | YOPH_YEREN | yop51 | yopH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50951.99 |
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| Organism: | Yersinia enterocolitica |
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| Description: | ChEMBL_965525 |
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| Residue: | 468 |
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| Sequence: | MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVL
SHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAA
LRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARA
TAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAV
RADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPD
YFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAV
SSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMN
DSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
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| BDBM50466475 |
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| n/a |
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| Name | BDBM50466475 |
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| Synonyms: | CHEMBL4292242 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N4O2S |
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| Mol. Mass. | 350.394 |
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| SMILES | [O-][N+](=O)c1ccc(\C=N\NC(=S)Nc2cccc3ccccc23)cc1 |
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| Structure | 
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