| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50467597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1796483 (CHEMBL4268600) |
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| IC50 | 4.3±n/a nM |
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| Citation |  Iida, T; Ubukata, M; Mitani, I; Nakagawa, Y; Maeda, K; Imai, H; Ogoshi, Y; Hotta, T; Sakata, S; Sano, R; Morinaga, H; Negoro, T; Oshida, S; Tanaka, M; Inaba, T Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity. Eur J Med Chem158:832-852 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50467597 |
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| n/a |
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| Name | BDBM50467597 |
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| Synonyms: | CHEMBL4283141 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClN3O2S |
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| Mol. Mass. | 373.857 |
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| SMILES | OCc1csc(NC(=O)c2ccc(CNc3ccccc3Cl)cc2)n1 |
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| Structure | 
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