| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT8 |
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| Ligand | BDBM50470505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1802987 (CHEMBL4275279) |
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| IC50 | 23000±n/a nM |
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| Citation |  Zhang, R; Wang, J; Zhao, L; Liu, S; Du, D; Ding, H; Chen, S; Yue, L; Liu, YC; Zhang, C; Liu, H; Luo, C Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening. Eur J Med Chem157:867-876 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT8 |
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| Name: | Histone acetyltransferase KAT8 |
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| Synonyms: | KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52413.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_796800 |
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| Residue: | 458 |
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| Sequence: | MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGET
YLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQ
KNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVD
KIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEI
YRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVG
YFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLS
YRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPK
LVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
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| BDBM50470505 |
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| n/a |
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| Name | BDBM50470505 |
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| Synonyms: | CHEMBL4279641 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H10N2O2S3 |
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| Mol. Mass. | 382.479 |
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| SMILES | Oc1cc(O)c2sc3nc(cc(-c4cccs4)c3c2n1)-c1cccs1 |
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| Structure | 
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