Reaction Details |
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Target | Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
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Ligand | BDBM50469900 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36463 (CHEMBL653116) |
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Ki | 2.0±n/a nM |
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Citation | Judd, DB; Dowle, MD; Middlemiss, D; Scopes, DI; Ross, BC; Jack, TI; Pass, M; Tranquillini, E; Hobson, JE; Panchal, TA Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability. J Med Chem37:3108-20 (1994) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor |
Synonyms: | Angiotensin II receptor | Type-1A/Type-1B/Type-2 angiotensin II receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 36477 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Type-1 angiotensin II receptor B |
Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40929.44 |
Organism: | RAT |
Description: | Angiotensin II AT1B 0 RAT::P29089 |
Residue: | 359 |
Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2 |
Name: | Type-2 angiotensin II receptor |
Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41346.62 |
Organism: | RAT |
Description: | Angiotensin II AT2 0 0::P35351 |
Residue: | 363 |
Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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Component 3 |
Name: | Type-1 angiotensin II receptor A |
Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40910.53 |
Organism: | RAT |
Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
Residue: | 359 |
Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50469900 |
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n/a |
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Name | BDBM50469900 |
Synonyms: | CHEMBL104252 |
Type | Small organic molecule |
Emp. Form. | C24H21BrClF3N4O4S |
Mol. Mass. | 633.865 |
SMILES | CCNC(=O)c1c(Cl)nc(CC)n1Cc1ccc2oc(c(Br)c2c1)-c1ccccc1NS(=O)(=O)C(F)(F)F |
Structure |
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