Reaction Details | |||
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Target | Gastrin/cholecystokinin type B receptor | ||
Ligand | BDBM50470612 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_48425 (CHEMBL660353) | ||
Ki | 2.2±n/a nM | ||
Citation | Kalindjian, SB; Buck, IM; Cushnir, JR; Dunstone, DJ; Hudson, ML; Low, CM; McDonald, IM; Pether, MJ; Steel, KI; Tozer, MJ Improving the affinity and selectivity of a nonpeptide series of cholecystokinin-B/gastrin receptor antagonists based on the dibenzobicyclo[2.2.2]octane skeleton. J Med Chem38:4294-302 (1995) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Gastrin/cholecystokinin type B receptor | |||
Name: | Gastrin/cholecystokinin type B receptor | ||
Synonyms: | Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 49196.59 | ||
Organism: | MOUSE | ||
Description: | Cholecystokinin A CCKBR MOUSE::P56481 | ||
Residue: | 453 | ||
Sequence: |
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BDBM50470612 | |||
n/a | |||
Name | BDBM50470612 | ||
Synonyms: | CHEMBL436209 | ||
Type | Small organic molecule | ||
Emp. Form. | C46H45N3O8 | ||
Mol. Mass. | 767.8648 | ||
SMILES | OC(=O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C(C3c4ccccc4C2c2ccccc32)C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(c1)C(O)=O |wU:9.9,TLB:19:21:31.36:24.29,44:45:49:43.42.48,48:43:50:47.49.46,48:47:50:43.42.44,37:22:31.36:24.29,25:24:21.22:31.36,35:36:21.22:24.29,THB:44:43:49:45.50.46,28:29:21.22:31.36,(19.63,-7.77,;18.28,-7,;18.28,-5.44,;16.94,-7.79,;15.59,-7.01,;14.26,-7.77,;12.94,-7,;11.38,-7.01,;10.98,-5.49,;10.28,-8.1,;10.69,-9.6,;11.77,-10.69,;13.25,-10.3,;14.33,-11.38,;13.94,-12.87,;15.04,-13.97,;12.45,-13.26,;11.37,-12.18,;8.79,-7.71,;7.29,-7.3,;7.75,-5.77,;2.67,-8.1,;3.67,-7.07,;3.67,-8.95,;5.65,-9.56,;7.45,-9.56,;8.72,-10.82,;8.07,-12.08,;6.09,-12.08,;4.93,-10.77,;2.69,-10.25,;.79,-10.83,;-.77,-11.41,;-2.3,-10.93,;-1.97,-9.88,;-.32,-9.21,;1.37,-9.5,;4.32,-5.93,;3.37,-5.02,;5.45,-5.26,;5.42,-3.95,;6.55,-3.28,;7.75,-3.57,;8.89,-3.15,;9.91,-4.25,;8.63,-3.89,;8.63,-2.53,;7.75,-1.49,;8.91,-1.89,;6.55,-1.98,;7.43,-4.37,;14.26,-9.33,;15.59,-10.11,;16.94,-9.34,;16.36,-11.44,;15.65,-13,;17.91,-11.45,)| | ||
Structure |