Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50471065

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_48427 (CHEMBL660355)

1.6±n/a nM

Citation

Kalindjian, SB; Buck, IM; Davies, JM; Dunstone, DJ; Hudson, ML; Low, CM; McDonald, IM; Pether, MJ; Steel, KI; Tozer, MJ; Vinter, JG Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons. J Med Chem39:1806-15 (1996) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50471065

n/a

Name

BDBM50471065

Synonyms:

CHEMBL296167

Type

Small organic molecule

Emp. Form.

C47H47N3O7

Mol. Mass.

765.892

SMILES

OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)CC2C(C3c4ccccc4C2c2ccccc32)C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(c1)C(O)=O |wD:9.9,TLB:44:45:49:43.42.48,37:22:29.24:36.31,28:29:22.21:36.31,35:36:22.21:29.24,25:24:22.21:36.31,THB:20:21:29.24:36.31,44:43:49:45.50.46,46:45:42:47.49.48,46:47:42:45.50.44,32:31:22.21:29.24,(8.01,-6.63,;9.37,-5.87,;10.71,-6.64,;9.37,-4.31,;8.05,-3.54,;8.05,-1.98,;6.95,-.88,;5.47,-.48,;5.23,1.05,;4.2,-1.35,;4.05,-2.9,;5.21,-3.96,;6.55,-3.18,;7.89,-3.96,;7.89,-5.51,;6.52,-6.29,;5.21,-5.51,;2.83,-.57,;1.51,-1.35,;1.51,-2.9,;1.18,-1.33,;-.3,-.93,;.88,-.85,;.17,-1.58,;-1.64,-1.11,;-1.36,.19,;-2.44,1.1,;-3.8,.71,;-4.09,-.59,;-3,-1.49,;-1.14,-1.86,;-.53,-3.49,;-.89,-4.71,;.13,-5.65,;1.47,-5.34,;1.8,-4.1,;.81,-3.2,;1.28,.65,;.76,2.13,;2.78,.35,;3.8,1.53,;5.02,2.46,;6.24,1.69,;7.4,2.63,;9.16,2.49,;7.89,3.4,;7.47,4.87,;5.82,4.86,;6.97,3.98,;4.6,3.92,;6.64,2.4,;9.39,-1.21,;10.74,-1.98,;10.74,-3.54,;12.08,-1.22,;12.1,.33,;13.42,-2.01,)|

Structure