| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50474735 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157824 (CHEMBL769428) |
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| IC50 | 83.0±n/a nM |
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| Citation |  Shin, SS; Byun, Y; Lim, KM; Choi, JK; Lee, KW; Moh, JH; Kim, JK; Jeong, YS; Kim, JY; Choi, YH; Koh, HJ; Park, YH; Oh, YI; Noh, MS; Chung, S In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. J Med Chem47:792-804 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
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| Type: | Protein |
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| Mol. Mass.: | 69020.39 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q05769 |
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| Residue: | 604 |
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| Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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| BDBM50474735 |
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| n/a |
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| Name | BDBM50474735 |
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| Synonyms: | CHEMBL434308 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16FNO4S |
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| Mol. Mass. | 361.387 |
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| SMILES | CC1(C)OC(=C(C1=O)c1ccccc1)c1ccc(c(F)c1)S(N)(=O)=O |c:4| |
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| Structure | 
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