| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50474774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_159256 (CHEMBL764083) |
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| IC50 | 71.2±n/a nM |
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| Citation |  Shin, SS; Byun, Y; Lim, KM; Choi, JK; Lee, KW; Moh, JH; Kim, JK; Jeong, YS; Kim, JY; Choi, YH; Koh, HJ; Park, YH; Oh, YI; Noh, MS; Chung, S In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. J Med Chem47:792-804 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_MOUSE | PGHS-1 | PHS 1 | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69044.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_10575 |
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| Residue: | 602 |
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| Sequence: | MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCD
CTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLT
VRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLA
QQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSF
QELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRST
EL
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| BDBM50474774 |
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| n/a |
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| Name | BDBM50474774 |
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| Synonyms: | CHEMBL352430 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17BrO4S |
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| Mol. Mass. | 421.305 |
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| SMILES | CC1(C)OC(=C(C1=O)c1ccc(Br)cc1)c1ccc(cc1)S(C)(=O)=O |c:4| |
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| Structure | 
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