| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl transferase type-1 subunit beta |
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| Ligand | BDBM50481909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_622367 (CHEMBL1100174) |
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| IC50 | 35000±n/a nM |
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| Citation |  Tan, KT; Guiu-Rozas, E; Bon, RS; Guo, Z; Delon, C; Wetzel, S; Arndt, S; Alexandrov, K; Waldmann, H; Goody, RS; Wu, YW; Blankenfeldt, W Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. J Med Chem52:8025-37 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl transferase type-1 subunit beta |
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| Name: | Geranylgeranyl transferase type-1 subunit beta |
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| Synonyms: | GGTase-I-beta | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGTB1_RAT | Pggt1b | Type I protein geranyl-geranyltransferase subunit beta | geranylgeranyltransferase type-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42414.77 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105008 |
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| Residue: | 377 |
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| Sequence: | MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSG
HIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQS
WKTKDSKQCSDNVHISS
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| BDBM50481909 |
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| n/a |
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| Name | BDBM50481909 |
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| Synonyms: | CHEMBL1075863 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H55N9O5 |
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| Mol. Mass. | 741.922 |
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| SMILES | CCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N(C)CCc1ccccn1 |r| |
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| Structure | 
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