BindingDB PrimarySearch

Found 24 hits with Last Name = 'wetzel' and Initial = 's'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM50323701 (2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...) Show SMILES Oc1ccc2CN(CCc2c1)C(=O)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institut für Molekulare Physiologie Curated by ChEMBL					Assay Description Displacement of [3H]estradiol from human ERalpha ligand binding domain expressed in Escherichia coli BL21 (DE3)				Nat Chem Biol 5: 585-92 (2009) Article DOI: 10.1038/nchembio.188 BindingDB Entry DOI: 10.7270/Q2MP53F2
Institut für Molekulare Physiologie Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50393328 (CHEMBL2152123) Show SMILES CC(N(O)C(N)=O)c1ccc(OCc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of 5-LOX				J Med Chem 55: 5989-6001 (2012) Article DOI: 10.1021/jm300288g BindingDB Entry DOI: 10.7270/Q2J38TPJ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4367 ((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of EGFR				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50040420 (4-Methoxy-4-[3-(naphthalen-2-yloxymethyl)-phenyl]-...) Show SMILES COC1(CCOCC1)c1cccc(COc2ccc3ccccc3c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of 5-LOX				J Med Chem 55: 5989-6001 (2012) Article DOI: 10.1021/jm300288g BindingDB Entry DOI: 10.7270/Q2J38TPJ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4363 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...) Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of EGFR				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) Show SMILES CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of BTK				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50323700 (CHEMBL1213616 \| N-(2-(dimethylamino)ethyl)-4-((nap...) Show SMILES CN(C)CCNC(=O)c1ccc(COc2ccc3ccccc3c2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of 5-LOX				J Med Chem 55: 5989-6001 (2012) Article DOI: 10.1021/jm300288g BindingDB Entry DOI: 10.7270/Q2J38TPJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50323700 (CHEMBL1213616 \| N-(2-(dimethylamino)ethyl)-4-((nap...) Show SMILES CN(C)CCNC(=O)c1ccc(COc2ccc3ccccc3c2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut für Molekulare Physiologie Curated by ChEMBL					Assay Description Inhibition of LOX5 in human whole blood assessed as inhibition of conversion of aracidonic acid to leukotrine				Nat Chem Biol 5: 585-92 (2009) Article DOI: 10.1038/nchembio.188 BindingDB Entry DOI: 10.7270/Q2MP53F2
Institut für Molekulare Physiologie Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481906 (CHEMBL1075839) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM5718 (2,6,9-Trisubstituted purine deriv. 26 \| 2-{[6-(ben...) Show SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin E				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM5718 (2,6,9-Trisubstituted purine deriv. 26 \| 2-{[6-(ben...) Show SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin B				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50323699 (2-(benzyloxy)naphthalene \| 2-Benzyloxy-naphthalene...) Show SMILES C(Oc1ccc2ccccc2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of 5-LOX				J Med Chem 55: 5989-6001 (2012) Article DOI: 10.1021/jm300288g BindingDB Entry DOI: 10.7270/Q2J38TPJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50323699 (2-(benzyloxy)naphthalene \| 2-Benzyloxy-naphthalene...) Show SMILES C(Oc1ccc2ccccc2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut für Molekulare Physiologie Curated by ChEMBL					Assay Description Inhibition of LOX5 in human whole blood assessed as inhibition of conversion of aracidonic acid to leukotrine				Nat Chem Biol 5: 585-92 (2009) Article DOI: 10.1038/nchembio.188 BindingDB Entry DOI: 10.7270/Q2MP53F2
Institut für Molekulare Physiologie Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481911 (CHEMBL1075809) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481907 (CHEMBL1075810) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50013515 ((+)-yohimbine \| (16alpha,17alpha)-17-hydroxyyohimb...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of His-tagged Cdc25A expressed in the Escherichia coli BL21(DE3) using p-nitrophenyl phosphate as substrate for 80 mins by spectrophotomet...				J Med Chem 55: 5989-6001 (2012) Article DOI: 10.1021/jm300288g BindingDB Entry DOI: 10.7270/Q2J38TPJ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM5718 (2,6,9-Trisubstituted purine deriv. 26 \| 2-{[6-(ben...) Show SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of ERK1/MAPK				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481909 (CHEMBL1075863) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481908 (CHEMBL1075861) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481910 (CHEMBL1075859) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus)	BDBM50481912 (CHEMBL1075865) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay				J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM4363 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...) Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of IRK				Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4
Institute of Molecular Physiology Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50323701 (2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...) Show SMILES Oc1ccc2CN(CCc2c1)C(=O)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
Institut für Molekulare Physiologie Curated by ChEMBL					Assay Description Binding affinity to human ERbeta ligand binding domain expressed in Escherichia coli BL21(DE3) cells assessed as recruitment of fluorescently labeled...				Nat Chem Biol 5: 585-92 (2009) Article DOI: 10.1038/nchembio.188 BindingDB Entry DOI: 10.7270/Q2MP53F2
Institut für Molekulare Physiologie Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50323701 (2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...) Show SMILES Oc1ccc2CN(CCc2c1)C(=O)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	275	n/a	n/a	n/a	n/a
Institut für Molekulare Physiologie Curated by ChEMBL					Assay Description Binding affinity to human ERalpha ligand binding domain expressed in Escherichia coli BL21(DE3) cells assessed as recruitment of fluorescently labele...				Nat Chem Biol 5: 585-92 (2009) Article DOI: 10.1038/nchembio.188 BindingDB Entry DOI: 10.7270/Q2MP53F2
Institut für Molekulare Physiologie Curated by ChEMBL					More data for this Ligand-Target Pair