| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM50339536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756696 (CHEMBL1805161) |
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| Ki | 150±n/a nM |
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| Citation |  Butini, S; Gemma, S; Brindisi, M; Borrelli, G; Fiorini, I; Samuele, A; Karytinos, A; Facchini, M; Lossani, A; Zanoli, S; Campiani, G; Novellino, E; Focher, F; Maga, G Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. Bioorg Med Chem Lett21:3935-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM50339536 |
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| n/a |
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| Name | BDBM50339536 |
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| Synonyms: | (+/-)-6-Ethyl-6-[4-[(2-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one | CHEMBL1688575 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21ClFNO2S |
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| Mol. Mass. | 477.978 |
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| SMILES | CCC1(Oc2ccccc2-n2cccc2C1=O)c1ccc(CSc2ccc(F)cc2Cl)cc1 |
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| Structure | 
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