Reaction Details |
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Target | Serine/threonine-protein kinase B-raf |
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Ligand | BDBM333550 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_766931 (CHEMBL1828156) |
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IC50 | 110±n/a nM |
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Citation | Holladay, MW; Campbell, BT; Rowbottom, MW; Chao, Q; Sprankle, KG; Lai, AG; Abraham, S; Setti, E; Faraoni, R; Tran, L; Armstrong, RC; Gunawardane, RN; Gardner, MF; Cramer, MD; Gitnick, D; Ator, MA; Dorsey, BD; Ruggeri, BR; Williams, M; Bhagwat, SS; James, J 4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors. Bioorg Med Chem Lett21:5342-6 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf |
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Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM333550 |
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n/a |
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Name | BDBM333550 |
Synonyms: | 1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-hydroxy- 6- methoxy- quinazolin- 4- yloxy)phenyl) urea | US9730937, Example 95 |
Type | Small organic molecule |
Emp. Form. | C23H23N5O5 |
Mol. Mass. | 449.4592 |
SMILES | COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1O |
Structure |
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