| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM50484893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810002 (CHEMBL2015111) |
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| IC50 | 26±n/a nM |
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| Citation |  Warmus, JS; Quinn, CL; Taylor, C; Murphy, ST; Johnson, TA; Limberakis, C; Ortwine, D; Bronstein, J; Pagano, P; Knafels, JD; Lightle, S; Mochalkin, I; Brideau, R; Podoll, T Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. Bioorg Med Chem Lett22:2536-43 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC |
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| Type: | Enzyme |
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| Mol. Mass.: | 33428.15 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | P47205 |
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| Residue: | 303 |
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| Sequence: | MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ
EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS
FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA
AAV
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| BDBM50484893 |
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| n/a |
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| Name | BDBM50484893 |
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| Synonyms: | CHEMBL2012197 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O4 |
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| Mol. Mass. | 382.4131 |
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| SMILES | Cn1nncc1[C@H](O)[C@](C)(OCc1ccc(cc1)-c1ccccc1)C(=O)NO |r| |
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| Structure | 
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