Reaction Details |
| Report a problem with these data |
Target | Presenilin-1 |
---|
Ligand | BDBM50484994 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_814406 (CHEMBL2019730) |
---|
IC50 | 10.00±n/a nM |
---|
Citation | Close, J; Heidebrecht, R; Hendrix, J; Li, C; Munoz, B; Surdi, L; Kattar, S; Tempest, P; Moses, P; Geng, X; Hughes, B; Smotrov, N; Moxham, C; Chapnick, J; Kariv, I; Nikov, G; Burke, JE; Deshmukh, S; Jeliazkova-Mecheva, V; Leach, JK; Diaz, D; Xu, L; Yang, Z; Kwei, G; Moy, L; Shah, S; Tanga, F; Kenefic, C; Savage, D; Shearman, M; Ball, RG; McNevin, MJ; Markarewicz, A; Miller, T Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors. Bioorg Med Chem Lett22:3203-7 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Presenilin-1 |
---|
Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
BDBM50484994 |
---|
n/a |
---|
Name | BDBM50484994 |
Synonyms: | CHEMBL2019019 |
Type | Small organic molecule |
Emp. Form. | C22H19ClF5NO4S |
Mol. Mass. | 523.901 |
SMILES | O[C@@H]1CN(CC[C@]1(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1(CC1)C(F)(F)F |r| |
Structure |
|