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TargetPolyphenol oxidase 2
LigandBDBM50485140
Substrate/Competitorn/a
Meas. Tech.ChEMBL_819627 (CHEMBL2033812)
IC50 10640±n/a nM
Citation Cho, JCRho, HSJoo, YHLee, CSLee, JAhn, SMKim, JEShin, SSPark, YHSuh, KDPark, SN Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities. Bioorg Med Chem Lett22:4159-62 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyphenol oxidase 2
Name:Polyphenol oxidase 2
Synonyms:Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:Protein
Mol. Mass.:63923.66
Organism:Agaricus bisporus (Common mushroom)
Description:O42713
Residue:556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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  Blast E-value cutoff:
BDBM50485140
n/a
NameBDBM50485140
Synonyms:CHEMBL2031847
TypeSmall organic molecule
Emp. Form.C14H12O7
Mol. Mass.292.2409
SMILESCOc1ccc(C(=O)OCc2cc(=O)c(O)co2)c(O)c1
Structure
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