| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50485871 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863635 (CHEMBL2175367) |
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| IC50 | 540±n/a nM |
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| Citation |  Kawasuji, T; Johns, BA; Yoshida, H; Taishi, T; Taoda, Y; Murai, H; Kiyama, R; Fuji, M; Yoshinaga, T; Seki, T; Kobayashi, M; Sato, A; Fujiwara, T Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore. J Med Chem55:8735-44 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50485871 |
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| n/a |
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| Name | BDBM50485871 |
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| Synonyms: | CHEMBL2171669 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16FN3O4 |
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| Mol. Mass. | 333.3143 |
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| SMILES | CN(C)C(=O)c1[nH]cc(C(=O)NCc2ccc(F)cc2)c(=O)c1O |
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| Structure | 
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