| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50486165 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885326 (CHEMBL2215189) |
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| IC50 | 110±n/a nM |
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| Citation |  Zhao, XZ; Maddali, K; Smith, SJ; Métifiot, M; Johnson, BC; Marchand, C; Hughes, SH; Pommier, Y; Burke, TR 6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors. Bioorg Med Chem Lett22:7309-13 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50486165 |
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| n/a |
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| Name | BDBM50486165 |
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| Synonyms: | CHEMBL2206762 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17BrClFN2O5S |
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| Mol. Mass. | 507.758 |
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| SMILES | Oc1cc(c2CN(Cc3ccc(F)c(Cl)c3)C(=O)c2c1O)S(=O)(=O)NCCCBr |
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| Structure | 
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