Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50029786 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_146892 (CHEMBL751666) |
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Ki | 127±n/a nM |
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Citation | Bertha, CM; Vilner, BJ; Mattson, MV; Bowen, WD; Becketts, K; Xu, H; Rothman, RB; Flippen-Anderson, JL; Rice, KC (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. J Med Chem38:4776-85 (1996) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40465.04 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
Residue: | 372 |
Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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BDBM50029786 |
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n/a |
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Name | BDBM50029786 |
Synonyms: | 5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-methyl-2-aza-bicyclo[3.3.1]nonan-7-one | CHEMBL143800 |
Type | Small organic molecule |
Emp. Form. | C23H25NO3 |
Mol. Mass. | 363.4495 |
SMILES | COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5| |
Structure |
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