| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50029902 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35272 (CHEMBL648577) |
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| Ki | >4±n/a nM |
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| Citation |  Salimbeni, A; Canevotti, R; Paleari, F; Poma, D; Caliari, S; Fici, F; Cirillo, R; Renzetti, AR; Subissi, A; Belvisi, L N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists. J Med Chem38:4806-20 (1996) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41107.81 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_36779 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVC
AFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFK
IILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
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| BDBM50029902 |
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| n/a |
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| Name | BDBM50029902 |
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| Synonyms: | 6-Butyl-2-methyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one | CHEMBL144016 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N6O |
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| Mol. Mass. | 400.4763 |
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| SMILES | CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
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| Structure | 
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