| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50490524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941354 (CHEMBL2330056) |
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| IC50 | 13±n/a nM |
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| Citation |  Procopiou, PA; Barrett, JW; Barton, NP; Begg, M; Clapham, D; Copley, RC; Ford, AJ; Graves, RH; Hall, DA; Hancock, AP; Hill, AP; Hobbs, H; Hodgson, ST; Jumeaux, C; Lacroix, YM; Miah, AH; Morriss, KM; Needham, D; Sheriff, EB; Slack, RJ; Smith, CE; Sollis, SL; Staton, H Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. J Med Chem56:1946-60 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41406.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51679 |
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| Residue: | 360 |
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| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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| BDBM50490524 |
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| n/a |
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| Name | BDBM50490524 |
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| Synonyms: | CHEMBL2326630 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClFN4O4S2 |
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| Mol. Mass. | 523 |
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| SMILES | COc1c(F)ccc2n(Cc3cccc(CNC(C)=O)c3)nc(NS(=O)(=O)c3ccc(Cl)s3)c12 |
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| Structure | 
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